Mitagation effect of leptin and neem leaf extract in experimental visceral leishmaniasis

Abstract

Introduction Mitigation effect of Leptin and Neem leaf extract in Experimental Visceral leishmaniasis Page 1 1.1. History Leishmaniasis has the history of more than 2000 years which dates back to the first century AD. The name leishmaniasis coined after Dr. William Leishman; a Glasgwegian doctor had been working with the British Army in Calcutta, India. For the first time, he discovered ovoid shaped bodies in the spleen tissue of a British soldier who was already suffering from long-lasting, low-grade fever, anemia, muscular atrophy and swelling of the spleen. He developed a stain in 1901 to detect Leishmania amastigotes that reside in the spleen tissue. He called this illness as “Dum Dum fever” based on the town name, and his findings published in 1903. Contemporarily, Charles Donovan also noticed a similar kind of symptoms in other kala-azar patients and published his findings after a few weeks of Leishman discovery. The amastigotes appeared in the tissue smears were officially called as Leishman-Donovan bodies and the causative parasite named as Leishmania donovani. Both Leishman and Donovan had been classified the genus Leishmanias by linking with kala-azar