Mitagation effect of leptin and neem leaf extract in experimental visceral leishmaniasis
Mitagation effect of leptin and neem leaf extract in experimental visceral leishmaniasis
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Date
2015-10
Authors
Dayakar. Alti
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Journal ISSN
Volume Title
Publisher
University of Hyderabad
Abstract
Introduction
Mitigation effect of Leptin and Neem leaf extract in Experimental Visceral leishmaniasis Page 1
1.1. History
Leishmaniasis has the history of more than 2000 years which dates back to the first
century AD. The name leishmaniasis coined after Dr. William Leishman; a Glasgwegian
doctor had been working with the British Army in Calcutta, India. For the first time, he
discovered ovoid shaped bodies in the spleen tissue of a British soldier who was already
suffering from long-lasting, low-grade fever, anemia, muscular atrophy and swelling of the
spleen. He developed a stain in 1901 to detect Leishmania amastigotes that reside in the
spleen tissue. He called this illness as “Dum Dum fever” based on the town name, and his
findings published in 1903. Contemporarily, Charles Donovan also noticed a similar kind of
symptoms in other kala-azar patients and published his findings after a few weeks of
Leishman discovery. The amastigotes appeared in the tissue smears were officially called as
Leishman-Donovan bodies and the causative parasite named as Leishmania donovani. Both
Leishman and Donovan had been classified the genus Leishmanias by linking with kala-azar