Animal Biology - Theses

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Activation of Wnt/B-catenin/Tef signaling pathway in gliomas : a potential target for nonsteroidal anti-inflammatory drugs celecoxib and diclofenac

(University of Hyderabad, 2010-03-10) Gangadhara Reddy, Sareddy ; Prakash Babu, P
Age induced changes and the role of Melatonin in the Neurophysiology of Suprachiasmatic nucleus of Rat

(University of Hyderabad, 2008-02-16) Kalyani, Dasari ; Anita Jagota
Age-Induced Desynchronization Between Clock And Immune Genes Expression In Microglia And Other Peripheral Clock In Male Wistar Rats : Chronobiotic Role of Curcumin

(University of Hyderabad, 2019) Neelesh babu,Thummadi ; Anita Jagota
Alterations in the neurotransmitter functions of glutamate and gaba in galactosamine induced fulminant hepatic failure and hyperammonemia

(University of Hyderabad, 1995-06-24) Reeba K.Vikramadithyan ; Murthy, Ch.R.K
Alternate cry toxin targets in a lepidopteran insect pest, achaea janata

(University of Hyderabad, 2012-03-21) Jacob, Thuirei Ningshen ; Aparna Dutta Gupta
Analysis of midgut regeneration in lepidopteran pest, achaea janata upon cry toxication

(University of Hyderabad, 2019) Narender ; Aparna Dutta Gupta
Anti-inflamatory and anti-proliferative properties of chebulagic acid, a COX- 2/5 -LOX dual inhibitor isolated from terminalia chebula

(U, 2008-12-18) Bharat Kumar Reddy, d. ; Reddanna, P
Anti-inflamatory properties of 1Alfa25(OH)2D3 and its analogs : inhibition of cyclooxygenase-2

(University of Hyderabad, 2004-12-14) Aparna, R. ; Reddanna, P
Anti-inflammatory effects of 15-lipoxygenase metabolites of α-linolenic acid;Studies on signalling pathways involved

(UNIVERSITY OF HYDERABAD, 2016-06-30) Naresh Kumar ; Reddanna, P
Antimicrobial responses in the male reproductive tract : insights into the regulatory mechanisms and the potential to limit infections

(University of Hyderabad, 2013-03-21) Biswas, B ; Suresh Yenugu
Antiproliferative effects of 15-Lipoxygenase metabolites on chronic myeloid leukemia cell line - K-562 : studies on molecular mechanisms

(University of Hyderabad, 2005-08-10) Vijaya Kumar Mahipal, S. ; Reddanna, P
Biochemical alterations in tryptophan metabolism leading to oxidative stress in brain during fulminant hepatic failure \b antioxidant protection by C-phycocyanin

(University of Hyderabad, 2006-03-30) Sathya Sai Kumar, K.V. ; Reddanna, P
Biochemical and functional genomic anslysis in mucobacteria : effect of iron limitation and mutational analysis of pykA and ald

(University of Hyderabad, 2007-03-10) Sivagami Sundaram, C.A.S ; Manjula Sritharan
Biodegradation of organophates \b Studies on horizontal gene transfer of organophosphates degrading gene clster and functional anslysis of mfhA found in plasmid-borne integrative mobilizable element of Sphingobium fuliginis ATCC 27551

(Univertsity of Hyderabad, 2013-06) Deviprasanna, Chakka ; Dayananda, Siddavattam

Xenobiotic compounds in a strict sense can be defined as man-made molecules that have never been exposed to any living organisms before their introduction into an environment. Broadly they are referred as chemicals that are present in significantly higher amounts than natural composition of an environment (TOP and SPRINGAEL 2003). As the chemical ligature found in these compounds are very new to the existing enzymes of living organisms (CASES and DE LORENZO 2001) most of them remain recalcitrant. However, because of the remarkable adaptive nature of the bacteria to extreme conditions of life, considerable numbers of anthropogenic compounds are found to be degradable. According to microbial genetists, three major strategies contribute for bacterial adaptation, rich biodiversity, long-lasting maintenance and development of life on earth (ARBER 2000) [Fig 1-1]. In the first strategy the small local gene sequence changes that occur during the development of a new process contribute for bacterial adaptation. However, in the absence of essential participation of natural selection development of a novel biological function is extremely rare (ARBER 1994). In the second strategy, recombination between related gene sequences results in DNA reshuffling which involves novel combination of existing capacities by the fusion of different functional domains. Third strategy is very efficient phenomenon of genetic variation in which, there is an exchange of evolutionary success between the micro-organisms. Due to such exchange micro-organisms can adapt to a sudden change in the surrounding conditions in a relatively short period of time (OCHMAN et al. 2000) (SPRINGAEL et al. 2002). This phenomenon of acquiring genetic material from neighbouring bacterial species is referred to as Horizontal (Lateral) gene transfer (HGT/LGT). In recent years, wide genome sequencing data available indicated the presence of identical metabolic pathways and enzymes for the degradation of xenobiotic compounds in phylogenetically unrelated bacterial strains isolated from Introduction 3 geographically distinct areas. Such results signifies the existence of similarities in the gene organizations and nucleotide sequences (SENTCHILO et al. 2000; SPRINGAEL et al. 2001) and supports for the of Arber’s third strategy of inter-genomic acquisition (HACKER and CARNIEL 2001)
Biodegradation of organophosphates : studies on membrane targeting of organophosphate hydrolase(OPH) and regulation of opd gene expression in Brevundimonas diminuta MG

(University of Hyderabad, 2010-02-16) Purushotham, Gorla ; Dayananda, S
C- Phycocyanin and celecoxib, selective COX-2 inhibitors, induce apoptosis in chronic myeloid leukemia cell line - K562

(University of Hyderabad, 2003-10) Subhashini, J. ; Reddanna, P
C-phycocyanin and arachidonic acid cascade : role in apoptosis of lipopolysaccharide stimulated mouse macrophage cell line, raw 264.7

(University of Hyderabad, 2001-12-29) Madhava Reddy, C. ; Reddanna, P
Cellular and molecular mechanisms involved in the postembryonic development in the central nervous system of holometabolous lepidopteran insect, bombyx mori

(University of Hyderabad, 2011-06-24) Shah, Kapil M. ; Anita Jagota
Cellular and Subcellular transport and metabolism of branched-chain amino acids in young, adult and aged Rat brain

(University of Hyderabad, 1995-06-22) Venkata Rama Rao, K ; Murthy, Ch.R.K
Cerebral ischemia/reperfusion injury in rats \b oxidative stress and role of antioxidants

(University of Hyderabad, 2005-01-18) Kranti Kumari, Naga ; Prakash Babu, P