Animal Biology - Publications

Permanent URI for this collection

https://dspace.uohyd.ac.in/handle/1/115

Browse

Browsing Animal Biology - Publications by Subject "1,3-Diarylpyrazoles"
  • Item
    Synthesis and in vitro anticancer and antitubercular activity of diarylpyrazole ligated dihydropyrimidines possessing lipophilic carbamoyl group
    ( 2012-04-15) Yadlapalli, Rama Krishna ; Chourasia, O. P. ; Vemuri, Kiranmayi ; Sritharan, Manjula ; Perali, Ramu Sridhar
    A series of dihydropyrimidine derivatives were synthesized by utilizing Biginelli reaction and evaluated for their in vitro anticancer activity against MCF-7 human breast cancer (HBC) cell line using sulforhodamine B (SRB) assay and antitubercular activity against Mycobacterium tuberculosis (MTB) H 37Rv using Microplate Alamar Blue Assay (MABA). Compounds 13p, 13t were exhibited 70.6% and 63.7% of HBC cell growth inhibition at 10 μM concentration. Interestingly compound 13p was also found to be the most potent in the series against MTB H 37Rv with MIC value of 0.125 μg/mL. © 2012 Elsevier Ltd. All rights reserved.