Synthesis and in vitro anticancer and antitubercular activity of diarylpyrazole ligated dihydropyrimidines possessing lipophilic carbamoyl group
Synthesis and in vitro anticancer and antitubercular activity of diarylpyrazole ligated dihydropyrimidines possessing lipophilic carbamoyl group
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Date
2012-04-15
Authors
Yadlapalli, Rama Krishna
Chourasia, O. P.
Vemuri, Kiranmayi
Sritharan, Manjula
Perali, Ramu Sridhar
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Abstract
A series of dihydropyrimidine derivatives were synthesized by utilizing Biginelli reaction and evaluated for their in vitro anticancer activity against MCF-7 human breast cancer (HBC) cell line using sulforhodamine B (SRB) assay and antitubercular activity against Mycobacterium tuberculosis (MTB) H 37Rv using Microplate Alamar Blue Assay (MABA). Compounds 13p, 13t were exhibited 70.6% and 63.7% of HBC cell growth inhibition at 10 μM concentration. Interestingly compound 13p was also found to be the most potent in the series against MTB H 37Rv with MIC value of 0.125 μg/mL. © 2012 Elsevier Ltd. All rights reserved.
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Keywords
1,3-Diarylpyrazoles,
Anticancer,
Antitubercular,
Dihydropyrimidines,
Multicomponent Reaction
Citation
Bioorganic and Medicinal Chemistry Letters. v.22(8)