School of Medical Sciences

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Browsing School of Medical Sciences by Subject "Acanthamoeba"
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    Acanthamoeba keratitis presenting as a plaque
    ( 2008-10-01) Sahu, Srikant K. ; Das, Sujata ; Sharma, Savitri ; Vemuganti, Geeta K.
    Purpose: To report a case of Acanthamoeba keratitis clinically presenting with a plaque-like lesion typical of fungal keratitis. Methods: A 55-year-old woman presented with a yellow plaque-like lesion on the cornea surrounded by an infiltrate. Smears and culture were taken. The plaque was removed and subjected to histopathological investigation. Results: Smear, culture, and histopathology results confirmed Acanthamoeba (cysts). The patient was treated with intensive topical medication. The infection resolved after 8 weeks of treatment. Conclusions: Acanthamoeba infection of cornea may present as a plaque-like lesion. In addition to topical medication, plaque removal helps in early resolution of the infection. © 2008 by Lippincott Williams & Wilkins.
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    Granulomatous inflammation in Acanthamoeba sclerokeratitis
    ( 2013-06-01) Chatterjee, Samrat ; Agrawal, Deepshikha ; Vemuganti, Geeta K.
    This report describes the histopathological findings in a patient with Acanthamoeba sclerokeratitis (ASK). A 58-year-old patient with ASK underwent enucleation and sections of the cornea and sclera were subjected to histopathology and immunohistochemistry with monoclonal mouse antihuman antibodies against T cell CD3 and B cell CD20 antigens. Hematoxylin and Eosin stained sections of the cornea revealed epithelial ulceration, Bowman's membrane destruction, stromal vascularization, infiltration with lymphocytes, plasma cells, and granulomatous inflammation with multinucleated giant cells (MNGC). The areas of scleritis showed complete disruption of sclera collagen, necrosis and infiltration with neutrophils, macrophages, lymphocytes, and granulomatous inflammation with MNGC. No cyst or trophozoites of Acanthamoeba were seen in the cornea or sclera. Immunophenotyping revealed that the population of lymphocytes was predominantly of T cells. Granulomatous inflammation in ASK is probably responsible for the continuance and progression of the scleritis and management protocols should include immunosuppressive agents alongside amoebicidal drugs.
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    Recurrent endophthalmitis due to Acanthamoeba
    ( 2007-02-01) Pathengay, Avinash ; Vemuganti, Geeta K. ; Shah, Gaurav Y. ; Das, Taraprasad ; Sharma, Savitri
    Although extremely rare, Acanthamoeba infection may present as recurrent endophthalmitis following penetrating injury. This report describes a 5-year-old boy who developed Acanthamoeba endophthalmitis following penetrating trauma. © 2007 Scientific Communications International Limited.