Chemical genomics / edited by Haian Fu.

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$a 9781139021500 (ebook)

$z 9780521889483 (hardback)

$a (UkCbUP)CR9781139021500

$y 202009211219 $z santha

$a UkCbUP $b eng $e rda $c UkCbUP

$a QH438.4.C45 $b C45 2012

$a 615/.7 $2 23

$a Chemical genomics / $c edited by Haian Fu.

$a Cambridge : $b Cambridge University Press, $c 2012.

$a 1 online resource (xi, 345 pages) : $b digital, PDF file(s).

$a text $b txt $2 rdacontent

$a computer $b c $2 rdamedia

$a online resource $b cr $2 rdacarrier

$a Title from publisher's bibliographic system (viewed on 05 Oct 2015).

$a Harnessing the power of chemistry for biology and medicine / Cheryl L. Meyerkord and Haian Fu -- Exploring biology with small organic molecules / Nicholas Aberle and Craig M. Crews -- Chemical proteomics: a global study of protein-small molecule interactions / Akihisa Matsuyama, Yoko Yashiroda, and Minoru Yoshida -- Diversity-oriented synthesis / Warren R.J.D. Galloway [and others] -- Targeted chemical libraries / Gregory P. Tochtrop and Ryan E. Looper -- Fragment-based ligand discovery / Sandra Bartoli, Antonella Squarcia, and Daniela Fattori -- Basics and principles for building natural product-based libraries for HTS / Ronald J. Quinn -- Essentials for high-throughput screening operations / Stewart P. Rudnicki [and others] -- High content analysis and screening: basics, instrumentation, and applications / Paul A. Johnston -- Phenotypic screens with model organisms / Grant N. Wheeler, Robert A. Field, and Matthew L. Tomlinson -- Screening informatics and cheminformatics / Melinda I. Sosa [and others] -- Basics of HTS assay design and optimization / Eduard A. Sergienko -- Molecular sensors for transcriptional and post-transcriptional assays / Douglas S. Auld and Natasha Thorne -- Time-resolved fluorescence resonance energy transfer technologies in HTS / Yuhong Du and Jonathan J. Havel -- Compound profiling with high-content screening methodology / Thomas Mayer and Stephan Schürer -- Use of transgenic zebrafish in a phenotypic screen for angiogenesis inhibitors / Jaeki Min [and others] -- Flow cytometry multiplexed screening methodologies / Virginia M. Salas [and others] -- Label-free biosensor technologies in small molecule modulator discovery / Yuhong Du [and others] -- Basic principles and practices of computer-aided drug design / Chao-Yie Yang, Denzil Bernard, and Shaomeng Wang -- Computational approach for drug target identification / Honglin Li [and others] -- Pharmacogenomics to link genetic background with therapeutic efficacy and safety / Mark M. Bouzyk, Weining Tang, and Brian Leyland-Jones -- Drugs, genomic response signatures, and customized cancer therapy / Rafael Rosell, Teresa Moran, and Miguel Taron -- Current drug targets and the druggable genome / Margaret A. Johns, Andreas Russ, and Haian Fu.

$a Advances in chemistry, biology and genomics coupled with laboratory automation and computational technologies have led to the rapid emergence of the multidisciplinary field of chemical genomics. This edited text, with contributions from experts in the field, discusses the new techniques and applications that help further the study of chemical genomics. The beginning chapters provide an overview of the basic principles of chemical biology and chemical genomics. This is followed by a technical section that describes the sources of small-molecule chemicals; the basics of high-throughput screening technologies; and various bioassays for biochemical-, cellular- and organism-based screens. The final chapters connect the chemical genomics field with personalized medicine and the druggable genome for future discovery of new therapeutics. This book will be valuable to researchers, professionals and graduate students in many fields, including biology, biomedicine and chemistry.

$a Chemogenomics.

$a Fu, Haian, $e editor.

$i Print version: $z 9780521889483

$u https://doi.org/10.1017/CBO9781139021500

$a VIRTUA