Analgesia [electronic resource] / edited by Christoph Stein.
| Call Number | 615 |
| Title | Analgesia edited by Christoph Stein. With contributions by numerous experts |
| Physical Description | VIII, 435 p. online resource. |
| Series | Handbook of Experimental Pharmacology, 0171-2004 ; 177 |
| Contents | Peripheral and Central Mechanisms of Pain Generation -- Drugs in Clinical Use -- Opioids -- Antipyretic Analgesics: Nonsteroidal Antiinflammatory Drugs, Selective COX-2 Inhibitors, Paracetamol and Pyrazolinones -- Local Anesthetics -- Serotonin Receptor Ligands: Treatments of Acute Migraine and Cluster Headache -- Anti-convulsants and Anti-depressants -- Compounds in Preclinical Development -- Neuropeptide and Kinin Antagonists -- Glutamate Receptor Ligands -- Adrenergic and Cholinergic Compounds -- Cannabinoids and Pain -- Future Targets in Analgesia Research -- Adenosine and ATP Receptors -- Ion Channels in Analgesia Research -- Protein Kinases as Potential Targets for the Treatment of Pathological Pain -- Pain Management Beyond Pharmacotherapy -- Placebo and Endogenous Mechanisms of Analgesia -- Limitations of Pharmacotherapy: Behavioral Approaches to Chronic Pain. |
| Summary | Analgesics are among the oldest drugs described, albeit not necessarily for medicinaluse. Forexample,theSumeriansisolatedopioids(probablyfortheir euphoric effects) in the third millennium b. c. and the use of willow bark (salicin) for fever was ?rst reported in the eighteenth century. Both types of drugs are still in use, but today they are supplemented by a wide array of substances ranging from antidepressants to ion channel blockers. Not all of theseareprescribedbyphysicians. Manycompoundsaresoldoverthecounter and thus available to the public for self-medication. As a result, analgesics are also the most misused class of drugs and are the culprit for a multitude of healthproblemsdueto untoward sideeffects. Thisvolumeattemptstosummarizethecurrentstateofknowledgeonme- anisms underlying the various effects of these drugs, their side effect pro?les, and their indications and contraindications in clinical use. It also gives - sights into current efforts to discover novel mechanisms underlying different types of pain generation and the resulting development of new modulating compounds. Theseefforts haveemergedmostlyas aconsequenceofthemore profound insights provided by molecular methods and of the now common use of animal models of pathological, rather than physiological, pain. These important issues are elaborated in the introductory chapter. In parallel, c- temporaryinterdisciplinarytreatmentapproacheshavetaughtusthatsomatic mechanisms alone cannot explain pain; it is an experience shaped as well by social context, memory, and other psychological phenomena. Thus, the book closes with two chapters putting pharmacological strategies into a broader perspective. All of these advancements culminate in the contemporary c- mon goal of developing mechanism-based rather than empiric approaches to thetreatment ofpain. |
| Added Author | Stein, Christoph. editor. SpringerLink (Online service) |
| Subject | MEDICINE. PHARMACOLOGY. Anesthesiology. Rheumatology. Neurosurgery. SURGERY. PSYCHOLOGY. Biomedicine. Pharmacology/Toxicology. Anesthesiology. Psychology, general. Rheumatology. Surgery. Neurosurgery. |
| Multimedia |
-
Libraries with this item
-
950 BiomedicalandLifeSciences(Springer-11642)
Total Ratings:
0
04556nam a22005895i 4500
001
vtls001568920
003
VRT
005
20170831185600.0
007
cr nn 008mamaa
008
170831s2007 gw | s |||| 0|eng d
020
$a 9783540338239 $9 978-3-540-33823-9
024
7
$a 10.1007/978-3-540-33823-9 $2 doi
035
$a (DE-He213)978-3-540-33823-9
039
9
$y 201708311856 $z santha
050
4
$a RM1-950
072
7
$a MMG $2 bicssc
072
7
$a MED071000 $2 bisacsh
082
0
4
$a 615 $2 23
245
1
0
$a Analgesia $h [electronic resource] / $c edited by Christoph Stein.
246
3
$a With contributions by numerous experts
264
1
$a Berlin, Heidelberg : $b Springer Berlin Heidelberg, $c 2007.
300
$a VIII, 435 p. $b online resource.
336
$a text $b txt $2 rdacontent
337
$a computer $b c $2 rdamedia
338
$a online resource $b cr $2 rdacarrier
347
$a text file $b PDF $2 rda
490
1
$a Handbook of Experimental Pharmacology, $x 0171-2004 ; $v 177
505
0
$a Peripheral and Central Mechanisms of Pain Generation -- Drugs in Clinical Use -- Opioids -- Antipyretic Analgesics: Nonsteroidal Antiinflammatory Drugs, Selective COX-2 Inhibitors, Paracetamol and Pyrazolinones -- Local Anesthetics -- Serotonin Receptor Ligands: Treatments of Acute Migraine and Cluster Headache -- Anti-convulsants and Anti-depressants -- Compounds in Preclinical Development -- Neuropeptide and Kinin Antagonists -- Glutamate Receptor Ligands -- Adrenergic and Cholinergic Compounds -- Cannabinoids and Pain -- Future Targets in Analgesia Research -- Adenosine and ATP Receptors -- Ion Channels in Analgesia Research -- Protein Kinases as Potential Targets for the Treatment of Pathological Pain -- Pain Management Beyond Pharmacotherapy -- Placebo and Endogenous Mechanisms of Analgesia -- Limitations of Pharmacotherapy: Behavioral Approaches to Chronic Pain.
520
$a Analgesics are among the oldest drugs described, albeit not necessarily for medicinaluse. Forexample,theSumeriansisolatedopioids(probablyfortheir euphoric effects) in the third millennium b. c. and the use of willow bark (salicin) for fever was ?rst reported in the eighteenth century. Both types of drugs are still in use, but today they are supplemented by a wide array of substances ranging from antidepressants to ion channel blockers. Not all of theseareprescribedbyphysicians. Manycompoundsaresoldoverthecounter and thus available to the public for self-medication. As a result, analgesics are also the most misused class of drugs and are the culprit for a multitude of healthproblemsdueto untoward sideeffects. Thisvolumeattemptstosummarizethecurrentstateofknowledgeonme- anisms underlying the various effects of these drugs, their side effect pro?les, and their indications and contraindications in clinical use. It also gives - sights into current efforts to discover novel mechanisms underlying different types of pain generation and the resulting development of new modulating compounds. Theseefforts haveemergedmostlyas aconsequenceofthemore profound insights provided by molecular methods and of the now common use of animal models of pathological, rather than physiological, pain. These important issues are elaborated in the introductory chapter. In parallel, c- temporaryinterdisciplinarytreatmentapproacheshavetaughtusthatsomatic mechanisms alone cannot explain pain; it is an experience shaped as well by social context, memory, and other psychological phenomena. Thus, the book closes with two chapters putting pharmacological strategies into a broader perspective. All of these advancements culminate in the contemporary c- mon goal of developing mechanism-based rather than empiric approaches to thetreatment ofpain.
650
0
$a MEDICINE.
650
0
$a PHARMACOLOGY.
650
0
$a Anesthesiology.
650
0
$a Rheumatology.
650
0
$a Neurosurgery.
650
0
$a SURGERY.
650
0
$a PSYCHOLOGY.
650
1
4
$a Biomedicine.
650
2
4
$a Pharmacology/Toxicology.
650
2
4
$a Anesthesiology.
650
2
4
$a Psychology, general.
650
2
4
$a Rheumatology.
650
2
4
$a Surgery.
650
2
4
$a Neurosurgery.
700
1
$a Stein, Christoph. $e editor.
710
2
$a SpringerLink (Online service)
773
0
$t Springer eBooks
776
0
8
$i Printed edition: $z 9783540338222
830
0
$a Handbook of Experimental Pharmacology, $x 0171-2004 ; $v 177
856
4
0
$u http://dx.doi.org/10.1007/978-3-540-33823-9
912
$a ZDB-2-SBL
950
$a Biomedical and Life Sciences (Springer-11642)
999
$a VIRTUA
No Reviews to Display
| Summary | Analgesics are among the oldest drugs described, albeit not necessarily for medicinaluse. Forexample,theSumeriansisolatedopioids(probablyfortheir euphoric effects) in the third millennium b. c. and the use of willow bark (salicin) for fever was ?rst reported in the eighteenth century. Both types of drugs are still in use, but today they are supplemented by a wide array of substances ranging from antidepressants to ion channel blockers. Not all of theseareprescribedbyphysicians. Manycompoundsaresoldoverthecounter and thus available to the public for self-medication. As a result, analgesics are also the most misused class of drugs and are the culprit for a multitude of healthproblemsdueto untoward sideeffects. Thisvolumeattemptstosummarizethecurrentstateofknowledgeonme- anisms underlying the various effects of these drugs, their side effect pro?les, and their indications and contraindications in clinical use. It also gives - sights into current efforts to discover novel mechanisms underlying different types of pain generation and the resulting development of new modulating compounds. Theseefforts haveemergedmostlyas aconsequenceofthemore profound insights provided by molecular methods and of the now common use of animal models of pathological, rather than physiological, pain. These important issues are elaborated in the introductory chapter. In parallel, c- temporaryinterdisciplinarytreatmentapproacheshavetaughtusthatsomatic mechanisms alone cannot explain pain; it is an experience shaped as well by social context, memory, and other psychological phenomena. Thus, the book closes with two chapters putting pharmacological strategies into a broader perspective. All of these advancements culminate in the contemporary c- mon goal of developing mechanism-based rather than empiric approaches to thetreatment ofpain. |
| Contents | Peripheral and Central Mechanisms of Pain Generation -- Drugs in Clinical Use -- Opioids -- Antipyretic Analgesics: Nonsteroidal Antiinflammatory Drugs, Selective COX-2 Inhibitors, Paracetamol and Pyrazolinones -- Local Anesthetics -- Serotonin Receptor Ligands: Treatments of Acute Migraine and Cluster Headache -- Anti-convulsants and Anti-depressants -- Compounds in Preclinical Development -- Neuropeptide and Kinin Antagonists -- Glutamate Receptor Ligands -- Adrenergic and Cholinergic Compounds -- Cannabinoids and Pain -- Future Targets in Analgesia Research -- Adenosine and ATP Receptors -- Ion Channels in Analgesia Research -- Protein Kinases as Potential Targets for the Treatment of Pathological Pain -- Pain Management Beyond Pharmacotherapy -- Placebo and Endogenous Mechanisms of Analgesia -- Limitations of Pharmacotherapy: Behavioral Approaches to Chronic Pain. |
| Subject | MEDICINE. PHARMACOLOGY. Anesthesiology. Rheumatology. Neurosurgery. SURGERY. PSYCHOLOGY. Biomedicine. Pharmacology/Toxicology. Anesthesiology. Psychology, general. Rheumatology. Surgery. Neurosurgery. |
| Multimedia |