Free-Radical-Induced DNA Damage and Its Repair [electronic resource] : A Chemical Perspective / by Clemens von Sonntag.

Sonntag, Clemens von.
Call Number
572
Author
Sonntag, Clemens von. author.
Title
Free-Radical-Induced DNA Damage and Its Repair A Chemical Perspective / by Clemens von Sonntag.
Physical Description
XX, 523 p. online resource.
Contents
Formation of Reactive Free Radicals in an Aqueous Environment -- The Hydroxyl Radical -- Hydrogen Atom and Hydrated Electron -- Inorganic Radicals -- Carbon-Centered Radicals -- Heteroatom-Centered Radicals -- Peroxyl Radicals -- Polymer Radicals -- Nucleobases, Nucleosides and Nucleotides -- Polynucleotides and Single-Stranded DNA Fragments -- DNA and Double-Stranded Oligonucleotides -- Methods.
Summary
Understanding of the molecular basis of DNA damage and its repair has increased dramatically in recent years, and substantial knowledge now exists concerning the products arising from free-radical attack on DNA. Free-radical DNA damage may lead to mutations, cancer, and cell death. Free radicals have various sources, notably ionizing radiation and oxidative stress. In radiotherapy for cancer and with some anticancer drugs, use is made of cell death by excessive DNA damage. The mechanisms leading to products of free-radical attack which have been studied in models and with small double-stranded DNA fragments are discussed in detail, and the basics of the underlying free-radical chemistry are dealt with in separate chapters.
Added Author
SpringerLink (Online service)
Subject
LIFE SCIENCES.
MOLECULAR BIOLOGY.
ORGANIC CHEMISTRY.
ONCOLOGY.
BIOCHEMISTRY.
CELL BIOLOGY.
Life Sciences.
Biochemistry, general.
Cell Biology.
Life Sciences, general.
Molecular Medicine.
Oncology.
Organic Chemistry.
Multimedia
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$a Understanding of the molecular basis of DNA damage and its repair has increased dramatically in recent years, and substantial knowledge now exists concerning the products arising from free-radical attack on DNA. Free-radical DNA damage may lead to mutations, cancer, and cell death. Free radicals have various sources, notably ionizing radiation and oxidative stress. In radiotherapy for cancer and with some anticancer drugs, use is made of cell death by excessive DNA damage. The mechanisms leading to products of free-radical attack which have been studied in models and with small double-stranded DNA fragments are discussed in detail, and the basics of the underlying free-radical chemistry are dealt with in separate chapters.
650
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$a LIFE SCIENCES.
650
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$a MOLECULAR BIOLOGY.
650
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$a ORGANIC CHEMISTRY.
650
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$a ONCOLOGY.
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$a BIOCHEMISTRY.
650
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$a CELL BIOLOGY.
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$a Life Sciences.
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2
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$a Biochemistry, general.
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$a Cell Biology.
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2
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$a Life Sciences, general.
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$a Molecular Medicine.
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$a Oncology.
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Summary
Understanding of the molecular basis of DNA damage and its repair has increased dramatically in recent years, and substantial knowledge now exists concerning the products arising from free-radical attack on DNA. Free-radical DNA damage may lead to mutations, cancer, and cell death. Free radicals have various sources, notably ionizing radiation and oxidative stress. In radiotherapy for cancer and with some anticancer drugs, use is made of cell death by excessive DNA damage. The mechanisms leading to products of free-radical attack which have been studied in models and with small double-stranded DNA fragments are discussed in detail, and the basics of the underlying free-radical chemistry are dealt with in separate chapters.
Contents
Formation of Reactive Free Radicals in an Aqueous Environment -- The Hydroxyl Radical -- Hydrogen Atom and Hydrated Electron -- Inorganic Radicals -- Carbon-Centered Radicals -- Heteroatom-Centered Radicals -- Peroxyl Radicals -- Polymer Radicals -- Nucleobases, Nucleosides and Nucleotides -- Polynucleotides and Single-Stranded DNA Fragments -- DNA and Double-Stranded Oligonucleotides -- Methods.
Subject
LIFE SCIENCES.
MOLECULAR BIOLOGY.
ORGANIC CHEMISTRY.
ONCOLOGY.
BIOCHEMISTRY.
CELL BIOLOGY.
Life Sciences.
Biochemistry, general.
Cell Biology.
Life Sciences, general.
Molecular Medicine.
Oncology.
Organic Chemistry.
Multimedia