Hepatitis Delta Virus [electronic resource] / edited by John L. Casey.

Call Number
616.9101
Title
Hepatitis Delta Virus edited by John L. Casey.
Physical Description
XII, 228 p. 18 illus., 1 illus. in color. online resource.
Series
Current Topics in Microbiology and Immunology, 0070-217X ; 307
Contents
Structure and Replication of Hepatitis Delta Virus RNA -- HDV RNA Replication: Ancient Relic or Primer? -- HDV Ribozymes -- RNA Editing in Hepatitis Delta Virus -- Post-translational Modification of Delta Antigen of Hepatitis D Virus -- The Role of the HBV Envelope Proteins in the HDV Replication Cycle -- Prenylation of HDAg and Antiviral Drug Development -- Hepatitis Delta Virus Genetic Variability: From Genotypes I, II, III to Eight Major Clades? -- Functional and Clinical Significance of Hepatitis D Virus Genotype II Infection -- Immunology of HDV Infection -- The Woodchuck Model of HDV Infection.
Summary
Since its discovery nearly 30 years ago, hepatitis delta virus (HDV) has continued to surprise and fascinate. At 1,680 nucleotides the HDV genome is the smallest known to infect man. It is unique among animal viruses, the closest known relatives being plant viroids. To compensate for its limited protein coding capacity, HDV relies heavily on host functions and on structural features of its circular RNA genome. HDV infection depends on hepatitis B virus as a helper, and increases the severity of liver disease caused by HBV alone. There is currently neither an effective HDV vaccine nor a generally accepted useful therapy for HDV infection. This volume encompasses recent developments in HDV research, from molecular virology to genetics to experimental investigation of new therapeutic and vaccine candidates.
Added Author
Casey, John L. editor.
SpringerLink (Online service)
Subject
MEDICINE.
MEDICAL MICROBIOLOGY.
VIROLOGY.
Biomedicine.
Virology.
Medical Microbiology.
Multimedia
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Summary
Since its discovery nearly 30 years ago, hepatitis delta virus (HDV) has continued to surprise and fascinate. At 1,680 nucleotides the HDV genome is the smallest known to infect man. It is unique among animal viruses, the closest known relatives being plant viroids. To compensate for its limited protein coding capacity, HDV relies heavily on host functions and on structural features of its circular RNA genome. HDV infection depends on hepatitis B virus as a helper, and increases the severity of liver disease caused by HBV alone. There is currently neither an effective HDV vaccine nor a generally accepted useful therapy for HDV infection. This volume encompasses recent developments in HDV research, from molecular virology to genetics to experimental investigation of new therapeutic and vaccine candidates.
Contents
Structure and Replication of Hepatitis Delta Virus RNA -- HDV RNA Replication: Ancient Relic or Primer? -- HDV Ribozymes -- RNA Editing in Hepatitis Delta Virus -- Post-translational Modification of Delta Antigen of Hepatitis D Virus -- The Role of the HBV Envelope Proteins in the HDV Replication Cycle -- Prenylation of HDAg and Antiviral Drug Development -- Hepatitis Delta Virus Genetic Variability: From Genotypes I, II, III to Eight Major Clades? -- Functional and Clinical Significance of Hepatitis D Virus Genotype II Infection -- Immunology of HDV Infection -- The Woodchuck Model of HDV Infection.
Subject
MEDICINE.
MEDICAL MICROBIOLOGY.
VIROLOGY.
Biomedicine.
Virology.
Medical Microbiology.
Multimedia