Molecular Analysis of B Lymphocyte Development and Activation [electronic resource] / edited by Harinder Singh, Rudolf Grosschedl.

Call Number
616.079
Title
Molecular Analysis of B Lymphocyte Development and Activation edited by Harinder Singh, Rudolf Grosschedl.
Physical Description
XI, 260 p. online resource.
Series
Current Topics in Microbiology and Immunology, 0070-217X ; 290
Contents
Gene Regulatory Networks Orchestrating B Cell Fate Specification, Commitment, and Differentiation -- Helix-Loop-Helix Proteins in Lymphocyte Lineage Determination -- Ikaros-Family Proteins: In Search of Molecular Functions During Lymphocyte Development -- Biochemistry of V(D)J Recombination -- The pre-B cell Receptor in B Cell Development: Recent Advances, Persistent Questions and Conserved Mechanisms -- Transcriptional Control of B Cell Activation -- Expression of MHC II Genes -- Class Switch Recombination: An Emerging Mechanism -- Blimp-1; Immunoglobulin Secretion and the Switch to Plasma Cells -- Wnt Signaling in Lymphopoiesis.
Summary
The B lymphocyte lineage represents an important paradigm for exploring the molecular mechanisms underlying cell fate specification, differentiation and cellular activation. In the past five years, major advances have been achieved in our understanding of the transcriptional control of early B cell development and terminal plasma cell differentiation. In addition new insights became available for the processes of B cell activation, class switch recombination and somatic hypermutation. Many of the new findings and their implications for a molecular understanding of B cell biology in particular and cell differentiation in general are covered in this volume.
Added Author
Singh, Harinder. editor.
Grosschedl, Rudolf. editor.
SpringerLink (Online service)
Subject
MEDICINE.
IMMUNOLOGY.
Biomedicine.
Immunology.
Multimedia
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$a The B lymphocyte lineage represents an important paradigm for exploring the molecular mechanisms underlying cell fate specification, differentiation and cellular activation. In the past five years, major advances have been achieved in our understanding of the transcriptional control of early B cell development and terminal plasma cell differentiation. In addition new insights became available for the processes of B cell activation, class switch recombination and somatic hypermutation. Many of the new findings and their implications for a molecular understanding of B cell biology in particular and cell differentiation in general are covered in this volume.
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Summary
The B lymphocyte lineage represents an important paradigm for exploring the molecular mechanisms underlying cell fate specification, differentiation and cellular activation. In the past five years, major advances have been achieved in our understanding of the transcriptional control of early B cell development and terminal plasma cell differentiation. In addition new insights became available for the processes of B cell activation, class switch recombination and somatic hypermutation. Many of the new findings and their implications for a molecular understanding of B cell biology in particular and cell differentiation in general are covered in this volume.
Contents
Gene Regulatory Networks Orchestrating B Cell Fate Specification, Commitment, and Differentiation -- Helix-Loop-Helix Proteins in Lymphocyte Lineage Determination -- Ikaros-Family Proteins: In Search of Molecular Functions During Lymphocyte Development -- Biochemistry of V(D)J Recombination -- The pre-B cell Receptor in B Cell Development: Recent Advances, Persistent Questions and Conserved Mechanisms -- Transcriptional Control of B Cell Activation -- Expression of MHC II Genes -- Class Switch Recombination: An Emerging Mechanism -- Blimp-1; Immunoglobulin Secretion and the Switch to Plasma Cells -- Wnt Signaling in Lymphopoiesis.
Subject
MEDICINE.
IMMUNOLOGY.
Biomedicine.
Immunology.
Multimedia