The Dopamine Receptors [electronic resource] / edited by Kim A. Neve.

Return to search

Call Number	616.8
Title	The Dopamine Receptors edited by Kim A. Neve.
Physical Description	XII, 648 p. 69 illus., 6 illus. in color. online resource.
Series	The Receptors
Contents	Historical Overview: Introduction to the Dopamine Receptors -- Gene and Promoter Structures of the Dopamine Receptors -- Structural Basis of Dopamine Receptor Activation -- Dopamine Receptor Subtype-Selective Drugs: D1-Like Receptors -- Dopamine Receptor Subtype-Selective Drugs: D2-Like Receptors -- Dopamine Receptor Signaling: Intracellular Pathways to Behavior -- Dopaminergic Modulation of Glutamatergic Signaling in Striatal Medium Spiny Neurons -- Regulation of Dopamine Receptor Trafficking and Responsiveness -- Dopamine Receptor-Interacting Proteins -- Dopamine Receptor Oligomerization -- Dopamine Receptor Modulation of Glutamatergic Neurotransmission -- Unraveling the Role of Dopamine Receptors In Vivo: Lessons from Knockout Mice -- Dopamine Receptors and Behavior: From Psychopharmacology to Mutant Models -- Dopamine Modulation of the Prefrontal Cortex and Cognitive Function -- In Vivo Imaging of Dopamine Receptors -- Dopamine Receptors and the Treatment of Schizophrenia -- Dopamine Receptor Subtypes in Reward and Relapse -- Dopamine Receptors and the Treatment of Parkinson’s Disease -- Dopamine Receptor Genetics in Neuropsychiatric Disorders.
Summary	Dopamine receptors are among the most validated drug targets for neuropsychiatric disorders such as schizophrenia and Parkinson’s disease, and are potential targets for other disorders such as substance abuse, depression, Tourette’s syndrome, and attention deficit hyperactivity disorder. The new knowledge brought from the creation and characterization of mice deficient in each of the subtypes and the development of increasingly subtype-selective agonists and antagonists has fueled many of the chapters new to this second edition, with the use of knock-out mice and subtype-selective drugs meriting discussion in stand-alone chapters. The field of G protein-coupled receptors has also advanced significantly since the first edition, with a model of GPCR signaling based on linear, compartmentalized pathways having been replaced by a more complex, richer model in which neurotransmitter effects are mediated by a signalplex composed of numerous signaling proteins, including multiple GPCRs, other types of receptors, such as ionotropic receptors, accessory and scaffolding proteins, and effectors. This second edition of Dopamine Receptors will be of interest to neurobiologists, pharmacologists and molecular biologists who study the brain, as well as neurologists working on psychiatric diseases.
Added Author	Neve, Kim A. editor. SpringerLink (Online service)
Subject	MEDICINE. HUMAN PHYSIOLOGY. NEUROSCIENCES. PHARMACOLOGY. Pharmaceutical technology. NEUROLOGY. NEUROBIOLOGY. Medicine & Public Health. Neurology. Neurosciences. Pharmacology/Toxicology. Neurobiology. Human Physiology. Pharmaceutical Sciences/Technology.
Multimedia	http://dx.doi.org/10.1007/978-1-60327-333-6

Libraries with this item

950	Biomedical and Life Sciences (Springer-11642)

Total Ratings: 0

Copies
MARC Record
Reviews
Details


No records found to display.

04267nam a22005775i 4500

001

vtls001568565

003

VRT

005

20170831183900.0

007

cr nn 008mamaa

008

170831s2010 xxu| s |||| 0|eng d

020

$a 9781603273336 $9 978-1-60327-333-6

024

$a 10.1007/978-1-60327-333-6 $2 doi

035

$a (DE-He213)978-1-60327-333-6

039

$y 201708311839 $z santha

050

$a RC346-429.2

072

$a MJN $2 bicssc

072

$a MED056000 $2 bisacsh

082

$a 616.8 $2 23

245

$a The Dopamine Receptors $h [electronic resource] / $c edited by Kim A. Neve.

264

$a Totowa, NJ : $b Humana Press : $b Imprint: Humana Press, $c 2010.

300

$a XII, 648 p. 69 illus., 6 illus. in color. $b online resource.

336

$a text $b txt $2 rdacontent

337

$a computer $b c $2 rdamedia

338

$a online resource $b cr $2 rdacarrier

347

$a text file $b PDF $2 rda

490

$a The Receptors

505

$a Historical Overview: Introduction to the Dopamine Receptors -- Gene and Promoter Structures of the Dopamine Receptors -- Structural Basis of Dopamine Receptor Activation -- Dopamine Receptor Subtype-Selective Drugs: D1-Like Receptors -- Dopamine Receptor Subtype-Selective Drugs: D2-Like Receptors -- Dopamine Receptor Signaling: Intracellular Pathways to Behavior -- Dopaminergic Modulation of Glutamatergic Signaling in Striatal Medium Spiny Neurons -- Regulation of Dopamine Receptor Trafficking and Responsiveness -- Dopamine Receptor-Interacting Proteins -- Dopamine Receptor Oligomerization -- Dopamine Receptor Modulation of Glutamatergic Neurotransmission -- Unraveling the Role of Dopamine Receptors In Vivo: Lessons from Knockout Mice -- Dopamine Receptors and Behavior: From Psychopharmacology to Mutant Models -- Dopamine Modulation of the Prefrontal Cortex and Cognitive Function -- In Vivo Imaging of Dopamine Receptors -- Dopamine Receptors and the Treatment of Schizophrenia -- Dopamine Receptor Subtypes in Reward and Relapse -- Dopamine Receptors and the Treatment of Parkinson’s Disease -- Dopamine Receptor Genetics in Neuropsychiatric Disorders.

520

$a Dopamine receptors are among the most validated drug targets for neuropsychiatric disorders such as schizophrenia and Parkinson’s disease, and are potential targets for other disorders such as substance abuse, depression, Tourette’s syndrome, and attention deficit hyperactivity disorder. The new knowledge brought from the creation and characterization of mice deficient in each of the subtypes and the development of increasingly subtype-selective agonists and antagonists has fueled many of the chapters new to this second edition, with the use of knock-out mice and subtype-selective drugs meriting discussion in stand-alone chapters. The field of G protein-coupled receptors has also advanced significantly since the first edition, with a model of GPCR signaling based on linear, compartmentalized pathways having been replaced by a more complex, richer model in which neurotransmitter effects are mediated by a signalplex composed of numerous signaling proteins, including multiple GPCRs, other types of receptors, such as ionotropic receptors, accessory and scaffolding proteins, and effectors. This second edition of Dopamine Receptors will be of interest to neurobiologists, pharmacologists and molecular biologists who study the brain, as well as neurologists working on psychiatric diseases.

650

$a MEDICINE.

650

$a HUMAN PHYSIOLOGY.

650

$a NEUROSCIENCES.

650

$a PHARMACOLOGY.

650

$a Pharmaceutical technology.

650

$a NEUROLOGY.

650

$a NEUROBIOLOGY.

650

$a Medicine & Public Health.

650

$a Neurology.

650

$a Neurosciences.

650

$a Pharmacology/Toxicology.

650

$a Neurobiology.

650

$a Human Physiology.

650

$a Pharmaceutical Sciences/Technology.

700

$a Neve, Kim A. $e editor.

710

$a SpringerLink (Online service)

773

$t Springer eBooks

776

$i Printed edition: $z 9781603273329

830

$a The Receptors

856

$u http://dx.doi.org/10.1007/978-1-60327-333-6

912

$a ZDB-2-SBL

950

$a Biomedical and Life Sciences (Springer-11642)

999

$a VIRTUA

No Reviews to Display

Summary	Dopamine receptors are among the most validated drug targets for neuropsychiatric disorders such as schizophrenia and Parkinson’s disease, and are potential targets for other disorders such as substance abuse, depression, Tourette’s syndrome, and attention deficit hyperactivity disorder. The new knowledge brought from the creation and characterization of mice deficient in each of the subtypes and the development of increasingly subtype-selective agonists and antagonists has fueled many of the chapters new to this second edition, with the use of knock-out mice and subtype-selective drugs meriting discussion in stand-alone chapters. The field of G protein-coupled receptors has also advanced significantly since the first edition, with a model of GPCR signaling based on linear, compartmentalized pathways having been replaced by a more complex, richer model in which neurotransmitter effects are mediated by a signalplex composed of numerous signaling proteins, including multiple GPCRs, other types of receptors, such as ionotropic receptors, accessory and scaffolding proteins, and effectors. This second edition of Dopamine Receptors will be of interest to neurobiologists, pharmacologists and molecular biologists who study the brain, as well as neurologists working on psychiatric diseases.
Contents	Historical Overview: Introduction to the Dopamine Receptors -- Gene and Promoter Structures of the Dopamine Receptors -- Structural Basis of Dopamine Receptor Activation -- Dopamine Receptor Subtype-Selective Drugs: D1-Like Receptors -- Dopamine Receptor Subtype-Selective Drugs: D2-Like Receptors -- Dopamine Receptor Signaling: Intracellular Pathways to Behavior -- Dopaminergic Modulation of Glutamatergic Signaling in Striatal Medium Spiny Neurons -- Regulation of Dopamine Receptor Trafficking and Responsiveness -- Dopamine Receptor-Interacting Proteins -- Dopamine Receptor Oligomerization -- Dopamine Receptor Modulation of Glutamatergic Neurotransmission -- Unraveling the Role of Dopamine Receptors In Vivo: Lessons from Knockout Mice -- Dopamine Receptors and Behavior: From Psychopharmacology to Mutant Models -- Dopamine Modulation of the Prefrontal Cortex and Cognitive Function -- In Vivo Imaging of Dopamine Receptors -- Dopamine Receptors and the Treatment of Schizophrenia -- Dopamine Receptor Subtypes in Reward and Relapse -- Dopamine Receptors and the Treatment of Parkinson’s Disease -- Dopamine Receptor Genetics in Neuropsychiatric Disorders.
Subject	MEDICINE. HUMAN PHYSIOLOGY. NEUROSCIENCES. PHARMACOLOGY. Pharmaceutical technology. NEUROLOGY. NEUROBIOLOGY. Medicine & Public Health. Neurology. Neurosciences. Pharmacology/Toxicology. Neurobiology. Human Physiology. Pharmaceutical Sciences/Technology.
Multimedia	http://dx.doi.org/10.1007/978-1-60327-333-6