The GABA Receptors [electronic resource] / edited by S. J. Enna, Hanns Möhler.
| Call Number | 612.8 |
| Title | The GABA Receptors edited by S. J. Enna, Hanns Möhler. |
| Edition | Third Edition. |
| Physical Description | X, 325 p. online resource. |
| Series | The Receptors |
| Contents | The GABA Receptors -- Functional Relevance of GABAA-Receptor Subtypes -- Trafficking of Postsynaptic GABAA Receptors by Receptor-Associated Proteins -- Subunit Composition and Structure of GABAA-Receptor Subtypes -- Differential Activation of GABAA-Receptor Subtypes -- GABAA-Receptor Mutations Associated With Idiopathic Generalized Epilepsies and Febrile Seizures -- Abuse and Dependence Liability of GABAA-Receptor Modulators -- Mechanisms of GABAA and GABAB Receptor Gene Regulation and Cell Surface Expression -- Chemistry of GABAB Modulators -- The Unusual Functioning of the GABAB-Receptor Heterodimer -- Characteristics of GABAB Receptor Mutant Mice -- GABAB Receptor ad a Potential Therapeutic Target. |
| Summary | This volume is the third edition of a monograph series that was first published in 1983. The demand for this work is a testament to the impact of studies on -aminobutyric acid (GABA) receptors on the basic understanding of synaptic transmission and on defining the clinical importance of the neurotransmitter system. Chronicled in The GABA Receptors, Third Edition, are the advances made in understanding the molecular and pharmacological properties of GABA A and GABA receptors since the topic was last reviewed in 1996. Particular B emphasis is placed on describing the assembly, structure, and function of GABA B sites, the first heterodimeric G protein-coupled receptors identified in vivo. In addition, there are reports dealing with the subunit composition, trafficking, and pharmacological selectivity of GABA receptors. Aside from providing A insights into the fundamental properties of ligand-gated ion channels and second messenger systems, the findings detailed in this work point the way for developing novel therapeutics capable of more selectively manipulating these transmitter sites. |
| Added Author | Enna, S. J. editor. Möhler, Hanns. editor. SpringerLink (Online service) |
| Subject | MEDICINE. NEUROSCIENCES. PHARMACOLOGY. PSYCHIATRY. CELL BIOLOGY. Biomedicine. Neurosciences. Pharmacology/Toxicology. Cell Biology. Psychiatry. |
| Multimedia |
-
Libraries with this item
-
950 BiomedicalandLifeSciences(Springer-11642)
Total Ratings:
0
03451nam a22005535i 4500
001
vtls001568544
003
VRT
005
20170831183800.0
007
cr nn 008mamaa
008
170831s2007 xxu| s |||| 0|eng d
020
$a 9781597454650 $9 978-1-59745-465-0
024
7
$a 10.1007/978-1-59745-465-0 $2 doi
035
$a (DE-He213)978-1-59745-465-0
039
9
$y 201708311838 $z santha
050
4
$a RC321-580
072
7
$a PSAN $2 bicssc
072
7
$a MED057000 $2 bisacsh
082
0
4
$a 612.8 $2 23
245
1
4
$a The GABA Receptors $h [electronic resource] / $c edited by S. J. Enna, Hanns Möhler.
250
$a Third Edition.
264
1
$a Totowa, NJ : $b Humana Press, $c 2007.
300
$a X, 325 p. $b online resource.
336
$a text $b txt $2 rdacontent
337
$a computer $b c $2 rdamedia
338
$a online resource $b cr $2 rdacarrier
347
$a text file $b PDF $2 rda
490
1
$a The Receptors
505
0
$a The GABA Receptors -- Functional Relevance of GABAA-Receptor Subtypes -- Trafficking of Postsynaptic GABAA Receptors by Receptor-Associated Proteins -- Subunit Composition and Structure of GABAA-Receptor Subtypes -- Differential Activation of GABAA-Receptor Subtypes -- GABAA-Receptor Mutations Associated With Idiopathic Generalized Epilepsies and Febrile Seizures -- Abuse and Dependence Liability of GABAA-Receptor Modulators -- Mechanisms of GABAA and GABAB Receptor Gene Regulation and Cell Surface Expression -- Chemistry of GABAB Modulators -- The Unusual Functioning of the GABAB-Receptor Heterodimer -- Characteristics of GABAB Receptor Mutant Mice -- GABAB Receptor ad a Potential Therapeutic Target.
520
$a This volume is the third edition of a monograph series that was first published in 1983. The demand for this work is a testament to the impact of studies on -aminobutyric acid (GABA) receptors on the basic understanding of synaptic transmission and on defining the clinical importance of the neurotransmitter system. Chronicled in The GABA Receptors, Third Edition, are the advances made in understanding the molecular and pharmacological properties of GABA A and GABA receptors since the topic was last reviewed in 1996. Particular B emphasis is placed on describing the assembly, structure, and function of GABA B sites, the first heterodimeric G protein-coupled receptors identified in vivo. In addition, there are reports dealing with the subunit composition, trafficking, and pharmacological selectivity of GABA receptors. Aside from providing A insights into the fundamental properties of ligand-gated ion channels and second messenger systems, the findings detailed in this work point the way for developing novel therapeutics capable of more selectively manipulating these transmitter sites.
650
0
$a MEDICINE.
650
0
$a NEUROSCIENCES.
650
0
$a PHARMACOLOGY.
650
0
$a PSYCHIATRY.
650
0
$a CELL BIOLOGY.
650
1
4
$a Biomedicine.
650
2
4
$a Neurosciences.
650
2
4
$a Pharmacology/Toxicology.
650
2
4
$a Cell Biology.
650
2
4
$a Psychiatry.
700
1
$a Enna, S. J. $e editor.
700
1
$a Möhler, Hanns. $e editor.
710
2
$a SpringerLink (Online service)
773
0
$t Springer eBooks
776
0
8
$i Printed edition: $z 9781588298133
830
0
$a The Receptors
856
4
0
$u http://dx.doi.org/10.1007/978-1-59745-465-0
912
$a ZDB-2-SBL
950
$a Biomedical and Life Sciences (Springer-11642)
999
$a VIRTUA
No Reviews to Display
| Summary | This volume is the third edition of a monograph series that was first published in 1983. The demand for this work is a testament to the impact of studies on -aminobutyric acid (GABA) receptors on the basic understanding of synaptic transmission and on defining the clinical importance of the neurotransmitter system. Chronicled in The GABA Receptors, Third Edition, are the advances made in understanding the molecular and pharmacological properties of GABA A and GABA receptors since the topic was last reviewed in 1996. Particular B emphasis is placed on describing the assembly, structure, and function of GABA B sites, the first heterodimeric G protein-coupled receptors identified in vivo. In addition, there are reports dealing with the subunit composition, trafficking, and pharmacological selectivity of GABA receptors. Aside from providing A insights into the fundamental properties of ligand-gated ion channels and second messenger systems, the findings detailed in this work point the way for developing novel therapeutics capable of more selectively manipulating these transmitter sites. |
| Contents | The GABA Receptors -- Functional Relevance of GABAA-Receptor Subtypes -- Trafficking of Postsynaptic GABAA Receptors by Receptor-Associated Proteins -- Subunit Composition and Structure of GABAA-Receptor Subtypes -- Differential Activation of GABAA-Receptor Subtypes -- GABAA-Receptor Mutations Associated With Idiopathic Generalized Epilepsies and Febrile Seizures -- Abuse and Dependence Liability of GABAA-Receptor Modulators -- Mechanisms of GABAA and GABAB Receptor Gene Regulation and Cell Surface Expression -- Chemistry of GABAB Modulators -- The Unusual Functioning of the GABAB-Receptor Heterodimer -- Characteristics of GABAB Receptor Mutant Mice -- GABAB Receptor ad a Potential Therapeutic Target. |
| Subject | MEDICINE. NEUROSCIENCES. PHARMACOLOGY. PSYCHIATRY. CELL BIOLOGY. Biomedicine. Neurosciences. Pharmacology/Toxicology. Cell Biology. Psychiatry. |
| Multimedia |