Adhesion-GPCRs [electronic resource] : Structure to Function / edited by Simon Yona, Martin Stacey.

Return to search

Call Number	612
Title	Adhesion-GPCRs Structure to Function / edited by Simon Yona, Martin Stacey.
Physical Description	XXI, 199 p. online resource.
Series	Advances in Experimental Medicine and Biology, 0065-2598 ; 706
Contents	The Adhesion GPCRs; Gene Repertoire, Phylogeny and Evolution -- 7TM-Cadherins: Developmental Roles and Future Challenges -- Latrophilin Signalling in Tissue Polarity and Morphogenesis -- GPS Proteolytic Cleavage of Adhesion-GPCRs -- The Latrophilins, “Split-Personality” Receptors -- Studies on the Very Large G Protein-Coupled Receptor: From Initial Discovery to Determining its Role in Sensorineural Deafness in Higher Animals -- Adhesion-GPCRs in the CNS -- GPR56 Interacts with Extracellular Matrix and Regulates Cancer Progression -- Adhesion-GPCRs in Tumorigenesis -- Immunity and Adhesion-GPCRs -- CD97 in Leukocyte Trafficking -- The Role of CD97 in Regulating Adaptive T-Cell Responses -- F4/80: The Macrophage-Specific Adhesion-GPCR and its Role in Immunoregulation -- Signal Transduction Mediated through Adhesion-GPCRs -- Emerging Roles of Brain-Specific Angiogenesis Inhibitor 1 -- Adhesion-GPCRs in the Male Reproductive Tract.
Summary	Upon completion of the human genome project over 800 G protein-coupled receptor 1 (GPCR) genes, subdivided into five categories, were identified. These receptors sense a diverse array of stimuli, including peptides, ions, lipid analogues, light and odour, in a discriminating fashion. Subsequently, they transduce a signal from the ligand–receptor complex into numerous cellular responses. The importance of GPCRs is further reflected in the fact that they constitute the most common target for therapeutic drugs across a 2 wide range of human disorders. Phylogenetic analysis of GPCRs produced the GRAFS classification system, which subdivides GPCRs into five discrete families: glutamate, rhodopsin, adhesion, frizzled/taste2 and secretin receptors. The adhesion-GPCR family 2 can be further subdivided into eight groups. The field of adhesion-GPCR biology has indeed become large enough to require a volume dedicated solely to this field. The contributors to this book have made a courageous effort to address the key concepts of adhesion-GPCR biology, including the evolution and biochemistry of adhesion-GPCRs; there are extensive discussions on the functional nature of these receptors during development, the immune response and tumourgenesis. Finally, there are chapters dedicated to adhesion-GPCR signalling, an area of intense investigation.
Added Author	Yona, Simon. editor. Stacey, Martin. editor. SpringerLink (Online service)
Subject	MEDICINE. HUMAN PHYSIOLOGY. MOLECULAR BIOLOGY. Biomedicine. Human Physiology. Biomedicine general. Molecular Medicine.
Multimedia	http://dx.doi.org/10.1007/978-1-4419-7913-1

Libraries with this item

950	Biomedical and Life Sciences (Springer-11642)

Total Ratings: 0

Copies
MARC Record
Reviews
Details


No records found to display.

03956nam a22005055i 4500

001

vtls001568490

003

VRT

005

20170831183600.0

007

cr nn 008mamaa

008

170831s2010 xxu| s |||| 0|eng d

020

$a 9781441979131 $9 978-1-4419-7913-1

024

$a 10.1007/978-1-4419-7913-1 $2 doi

035

$a (DE-He213)978-1-4419-7913-1

039

$y 201708311836 $z santha

050

$a QP34-38

072

$a MFG $2 bicssc

072

$a MED075000 $2 bisacsh

082

$a 612 $2 23

245

$a Adhesion-GPCRs $h [electronic resource] : $b Structure to Function / $c edited by Simon Yona, Martin Stacey.

264

$a Boston, MA : $b Springer US, $c 2010.

300

$a XXI, 199 p. $b online resource.

336

$a text $b txt $2 rdacontent

337

$a computer $b c $2 rdamedia

338

$a online resource $b cr $2 rdacarrier

347

$a text file $b PDF $2 rda

490

$a Advances in Experimental Medicine and Biology, $x 0065-2598 ; $v 706

505

$a The Adhesion GPCRs; Gene Repertoire, Phylogeny and Evolution -- 7TM-Cadherins: Developmental Roles and Future Challenges -- Latrophilin Signalling in Tissue Polarity and Morphogenesis -- GPS Proteolytic Cleavage of Adhesion-GPCRs -- The Latrophilins, “Split-Personality” Receptors -- Studies on the Very Large G Protein-Coupled Receptor: From Initial Discovery to Determining its Role in Sensorineural Deafness in Higher Animals -- Adhesion-GPCRs in the CNS -- GPR56 Interacts with Extracellular Matrix and Regulates Cancer Progression -- Adhesion-GPCRs in Tumorigenesis -- Immunity and Adhesion-GPCRs -- CD97 in Leukocyte Trafficking -- The Role of CD97 in Regulating Adaptive T-Cell Responses -- F4/80: The Macrophage-Specific Adhesion-GPCR and its Role in Immunoregulation -- Signal Transduction Mediated through Adhesion-GPCRs -- Emerging Roles of Brain-Specific Angiogenesis Inhibitor 1 -- Adhesion-GPCRs in the Male Reproductive Tract.

520

$a Upon completion of the human genome project over 800 G protein-coupled receptor 1 (GPCR) genes, subdivided into five categories, were identified. These receptors sense a diverse array of stimuli, including peptides, ions, lipid analogues, light and odour, in a discriminating fashion. Subsequently, they transduce a signal from the ligand–receptor complex into numerous cellular responses. The importance of GPCRs is further reflected in the fact that they constitute the most common target for therapeutic drugs across a 2 wide range of human disorders. Phylogenetic analysis of GPCRs produced the GRAFS classification system, which subdivides GPCRs into five discrete families: glutamate, rhodopsin, adhesion, frizzled/taste2 and secretin receptors. The adhesion-GPCR family 2 can be further subdivided into eight groups. The field of adhesion-GPCR biology has indeed become large enough to require a volume dedicated solely to this field. The contributors to this book have made a courageous effort to address the key concepts of adhesion-GPCR biology, including the evolution and biochemistry of adhesion-GPCRs; there are extensive discussions on the functional nature of these receptors during development, the immune response and tumourgenesis. Finally, there are chapters dedicated to adhesion-GPCR signalling, an area of intense investigation.

650

$a MEDICINE.

650

$a HUMAN PHYSIOLOGY.

650

$a MOLECULAR BIOLOGY.

650

$a Biomedicine.

650

$a Human Physiology.

650

$a Biomedicine general.

650

$a Molecular Medicine.

700

$a Yona, Simon. $e editor.

700

$a Stacey, Martin. $e editor.

710

$a SpringerLink (Online service)

773

$t Springer eBooks

776

$i Printed edition: $z 9781441979124

830

$a Advances in Experimental Medicine and Biology, $x 0065-2598 ; $v 706

856

$u http://dx.doi.org/10.1007/978-1-4419-7913-1

912

$a ZDB-2-SBL

950

$a Biomedical and Life Sciences (Springer-11642)

999

$a VIRTUA

No Reviews to Display

Summary	Upon completion of the human genome project over 800 G protein-coupled receptor 1 (GPCR) genes, subdivided into five categories, were identified. These receptors sense a diverse array of stimuli, including peptides, ions, lipid analogues, light and odour, in a discriminating fashion. Subsequently, they transduce a signal from the ligand–receptor complex into numerous cellular responses. The importance of GPCRs is further reflected in the fact that they constitute the most common target for therapeutic drugs across a 2 wide range of human disorders. Phylogenetic analysis of GPCRs produced the GRAFS classification system, which subdivides GPCRs into five discrete families: glutamate, rhodopsin, adhesion, frizzled/taste2 and secretin receptors. The adhesion-GPCR family 2 can be further subdivided into eight groups. The field of adhesion-GPCR biology has indeed become large enough to require a volume dedicated solely to this field. The contributors to this book have made a courageous effort to address the key concepts of adhesion-GPCR biology, including the evolution and biochemistry of adhesion-GPCRs; there are extensive discussions on the functional nature of these receptors during development, the immune response and tumourgenesis. Finally, there are chapters dedicated to adhesion-GPCR signalling, an area of intense investigation.
Contents	The Adhesion GPCRs; Gene Repertoire, Phylogeny and Evolution -- 7TM-Cadherins: Developmental Roles and Future Challenges -- Latrophilin Signalling in Tissue Polarity and Morphogenesis -- GPS Proteolytic Cleavage of Adhesion-GPCRs -- The Latrophilins, “Split-Personality” Receptors -- Studies on the Very Large G Protein-Coupled Receptor: From Initial Discovery to Determining its Role in Sensorineural Deafness in Higher Animals -- Adhesion-GPCRs in the CNS -- GPR56 Interacts with Extracellular Matrix and Regulates Cancer Progression -- Adhesion-GPCRs in Tumorigenesis -- Immunity and Adhesion-GPCRs -- CD97 in Leukocyte Trafficking -- The Role of CD97 in Regulating Adaptive T-Cell Responses -- F4/80: The Macrophage-Specific Adhesion-GPCR and its Role in Immunoregulation -- Signal Transduction Mediated through Adhesion-GPCRs -- Emerging Roles of Brain-Specific Angiogenesis Inhibitor 1 -- Adhesion-GPCRs in the Male Reproductive Tract.
Subject	MEDICINE. HUMAN PHYSIOLOGY. MOLECULAR BIOLOGY. Biomedicine. Human Physiology. Biomedicine general. Molecular Medicine.
Multimedia	http://dx.doi.org/10.1007/978-1-4419-7913-1