The Rho GTPases in Cancer [electronic resource] / edited by Kenneth Golen.

Call Number
614.5999
Title
The Rho GTPases in Cancer edited by Kenneth Golen.
Physical Description
XXII, 206 p. online resource.
Contents
An Overview of the Rho GTPases -- Overview of Rho GTPase History -- Rho Proteins in Cancer -- The Rho Regulatory Proteins in Cancer -- RhoGDIs in Cancer -- Signaling through Galpha12/13 and RGS-RhoGEFs -- Vav Proteins in Cancer -- Rho GTPase-Activating Proteins in Cancer -- The Rho GTPase Proteins and Cancer -- RhoBTB Proteins in Cancer -- RhoC GTPase in Cancer Progression and Metastasis -- RhoB GTPase and FTIs in Cancer -- Regulation of Rho GTPase Activity Through Phosphorylation Events: A Brief Overview -- The Rho-Regulated ROCK Kinases in Cancer.
Summary
The Rho GTPases in Cancer is the first volume to collect and summarize the current understanding of the Rho GTPases and their involvement in the progression of human cancer. The critical role of the Rho GTPases, their regulatory proteins, and their effectors in cancer progression has become increasingly evident over the past decade. As translational research increases on these proteins, their importance as keystone molecules in vital cellular process is highlighted. Thus, these molecules represent a major class of potential therapeutic targets that could be exploited clinically. This aspect of Rho GTPase biology is developing, therefore the contents of The Rho GTPases in Cancer should prove of interest to clinicians and members of the cancer research community wishing to develop new treatments for cancer.
Added Author
Golen, Kenneth. editor.
SpringerLink (Online service)
Subject
MEDICINE.
CANCER RESEARCH.
PHARMACOLOGY.
CELL BIOLOGY.
Biomedicine.
Cancer Research.
Cell Biology.
Pharmacology/Toxicology.
Multimedia
  • Libraries with this item
Total Ratings: 0
No records found to display.
 
 
 
02864nam a22004815i 4500
001
 
 
vtls001568380
003
 
 
VRT
005
 
 
20170831183100.0
007
 
 
cr nn 008mamaa
008
 
 
170831s2010    xxu|    s    |||| 0|eng d
020
$a 9781441911117 $9 978-1-4419-1111-7
024
7
$a 10.1007/978-1-4419-1111-7 $2 doi
035
$a (DE-He213)978-1-4419-1111-7
039
9
$a 201708311831 $b santha $y 201708311322 $z vjs2012
050
4
$a RC261-271
072
7
$a MJCL $2 bicssc
072
7
$a MED062000 $2 bisacsh
082
0
4
$a 614.5999 $2 23
245
1
4
$a The Rho GTPases in Cancer $h [electronic resource] / $c edited by Kenneth Golen.
264
1
$a New York, NY : $b Springer New York, $c 2010.
300
$a XXII, 206 p. $b online resource.
336
$a text $b txt $2 rdacontent
337
$a computer $b c $2 rdamedia
338
$a online resource $b cr $2 rdacarrier
347
$a text file $b PDF $2 rda
505
0
$a An Overview of the Rho GTPases -- Overview of Rho GTPase History -- Rho Proteins in Cancer -- The Rho Regulatory Proteins in Cancer -- RhoGDIs in Cancer -- Signaling through Galpha12/13 and RGS-RhoGEFs -- Vav Proteins in Cancer -- Rho GTPase-Activating Proteins in Cancer -- The Rho GTPase Proteins and Cancer -- RhoBTB Proteins in Cancer -- RhoC GTPase in Cancer Progression and Metastasis -- RhoB GTPase and FTIs in Cancer -- Regulation of Rho GTPase Activity Through Phosphorylation Events: A Brief Overview -- The Rho-Regulated ROCK Kinases in Cancer.
520
$a The Rho GTPases in Cancer is the first volume to collect and summarize the current understanding of the Rho GTPases and their involvement in the progression of human cancer. The critical role of the Rho GTPases, their regulatory proteins, and their effectors in cancer progression has become increasingly evident over the past decade. As translational research increases on these proteins, their importance as keystone molecules in vital cellular process is highlighted. Thus, these molecules represent a major class of potential therapeutic targets that could be exploited clinically. This aspect of Rho GTPase biology is developing, therefore the contents of The Rho GTPases in Cancer should prove of interest to clinicians and members of the cancer research community wishing to develop new treatments for cancer.
650
0
$a MEDICINE.
650
0
$a CANCER RESEARCH.
650
0
$a PHARMACOLOGY.
650
0
$a CELL BIOLOGY.
650
1
4
$a Biomedicine.
650
2
4
$a Cancer Research.
650
2
4
$a Cell Biology.
650
2
4
$a Pharmacology/Toxicology.
700
1
$a Golen, Kenneth. $e editor.
710
2
$a SpringerLink (Online service)
773
0
$t Springer eBooks
776
0
8
$i Printed edition: $z 9781441911100
856
4
0
$u http://dx.doi.org/10.1007/978-1-4419-1111-7
912
$a ZDB-2-SBL
950
$a Biomedical and Life Sciences (Springer-11642)
999
$a VIRTUA               
No Reviews to Display
Summary
The Rho GTPases in Cancer is the first volume to collect and summarize the current understanding of the Rho GTPases and their involvement in the progression of human cancer. The critical role of the Rho GTPases, their regulatory proteins, and their effectors in cancer progression has become increasingly evident over the past decade. As translational research increases on these proteins, their importance as keystone molecules in vital cellular process is highlighted. Thus, these molecules represent a major class of potential therapeutic targets that could be exploited clinically. This aspect of Rho GTPase biology is developing, therefore the contents of The Rho GTPases in Cancer should prove of interest to clinicians and members of the cancer research community wishing to develop new treatments for cancer.
Contents
An Overview of the Rho GTPases -- Overview of Rho GTPase History -- Rho Proteins in Cancer -- The Rho Regulatory Proteins in Cancer -- RhoGDIs in Cancer -- Signaling through Galpha12/13 and RGS-RhoGEFs -- Vav Proteins in Cancer -- Rho GTPase-Activating Proteins in Cancer -- The Rho GTPase Proteins and Cancer -- RhoBTB Proteins in Cancer -- RhoC GTPase in Cancer Progression and Metastasis -- RhoB GTPase and FTIs in Cancer -- Regulation of Rho GTPase Activity Through Phosphorylation Events: A Brief Overview -- The Rho-Regulated ROCK Kinases in Cancer.
Subject
MEDICINE.
CANCER RESEARCH.
PHARMACOLOGY.
CELL BIOLOGY.
Biomedicine.
Cancer Research.
Cell Biology.
Pharmacology/Toxicology.
Multimedia