Cell-Extracellular Matrix Interactions in Cancer [electronic resource] / edited by Roy Zent, Ambra Pozzi.

Call Number
614.5999
Title
Cell-Extracellular Matrix Interactions in Cancer edited by Roy Zent, Ambra Pozzi.
Edition
1.
Physical Description
XII, 314 p. With 1 4-page color insert. online resource.
Contents
The Extracellular Matrix: An Overview -- Integrin Structure and Function -- Cancer in Context: Importance of the Tumor Microenvironment -- Basement Membrane Collagens and Cancer -- Laminins and Cancer Progression -- Fibronectins and Their Receptors in Cancer -- Vitronectin-Binding Integrins in Cancer -- The Function of SPARC in Tumor Cell Biology: SPARC as a Modulator of Cell–Extracellular Matrix Interaction -- Proteoglycans and Cancer -- Tetraspanins in Cancer -- The Role of Integrin-Linked Kinase in Cancer Development and Progression -- Focal Adhesion Kinase with the Interacting Proteins and Signaling in Cancer.
Summary
Cells require interactions with extracellular matrix (ECM) components in order to undergo normal morphogenesis with respect to organogenesis. ECM plays a significant role in regulating numerous cellular functions, like cell shape, adhesion, migration, proliferation, polarity, differentiation and apoptosis. In pathological conditions such as cancer, increased synthesis of certain ECM components and/or increased breakdown with consequent generation of ECM cleavage products can contribute to cancer growth and progression. That many growth factors (i.e. FGF, VEGF) are stored in the ECM milieu and are released upon protease-dependent cleavage further confirms the importance of ECM in regulating cell functions. Cell-Extracellular Matrix Interactions in Cancer describes how ECM creates a niche for tumor formation and the contribution of ECM components and their respective receptors in the development and spread of cancer.
Added Author
Zent, Roy. editor.
Pozzi, Ambra. editor.
SpringerLink (Online service)
Subject
MEDICINE.
CANCER RESEARCH.
PHARMACOLOGY.
CELL BIOLOGY.
Biomedicine.
Cancer Research.
Cell Biology.
Pharmacology/Toxicology.
Multimedia
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$a Cell Biology.
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Summary
Cells require interactions with extracellular matrix (ECM) components in order to undergo normal morphogenesis with respect to organogenesis. ECM plays a significant role in regulating numerous cellular functions, like cell shape, adhesion, migration, proliferation, polarity, differentiation and apoptosis. In pathological conditions such as cancer, increased synthesis of certain ECM components and/or increased breakdown with consequent generation of ECM cleavage products can contribute to cancer growth and progression. That many growth factors (i.e. FGF, VEGF) are stored in the ECM milieu and are released upon protease-dependent cleavage further confirms the importance of ECM in regulating cell functions. Cell-Extracellular Matrix Interactions in Cancer describes how ECM creates a niche for tumor formation and the contribution of ECM components and their respective receptors in the development and spread of cancer.
Contents
The Extracellular Matrix: An Overview -- Integrin Structure and Function -- Cancer in Context: Importance of the Tumor Microenvironment -- Basement Membrane Collagens and Cancer -- Laminins and Cancer Progression -- Fibronectins and Their Receptors in Cancer -- Vitronectin-Binding Integrins in Cancer -- The Function of SPARC in Tumor Cell Biology: SPARC as a Modulator of Cell–Extracellular Matrix Interaction -- Proteoglycans and Cancer -- Tetraspanins in Cancer -- The Role of Integrin-Linked Kinase in Cancer Development and Progression -- Focal Adhesion Kinase with the Interacting Proteins and Signaling in Cancer.
Subject
MEDICINE.
CANCER RESEARCH.
PHARMACOLOGY.
CELL BIOLOGY.
Biomedicine.
Cancer Research.
Cell Biology.
Pharmacology/Toxicology.
Multimedia