Thrombin [electronic resource] : Physiology and Disease / edited by Michael E. Maragoudakis, Nikos E. Tsopanoglou.

Call Number
612
Title
Thrombin Physiology and Disease / edited by Michael E. Maragoudakis, Nikos E. Tsopanoglou.
Physical Description
XII, 266 p. online resource.
Contents
Thrombin: Structure, Functions, and Regulation -- Thrombin: To PAR or Not to PAR, and the Regulation of Inflammation -- Regulation of Thrombin Receptor Signaling -- Thrombin-Activated Protein C: Integrated to Regulate Vascular Physiology -- The Role of Thrombin in Vascular Development -- The Role of Thrombin in Angiogenesis -- Thrombin and Thrombin Peptides in Wound Healing and Tissue Repair -- The Role of Thrombin and Thrombin Receptors in the Brain -- The Role of Thrombin in Tumor Biology -- The Role of Thrombin and its Receptors in Epithelial Malignancies: Lessons from a Transgenic Mouse Model and Transcriptional Regulation -- Anti-thrombotic Therapy in Cancer Patients -- Thrombin Receptor Modulators: Medicinal Chemistry, Biological Evaluation, and Clinical Application -- Novel Anticoagulant Therapy: Principle and Practice.
Summary
It has become increasingly evident in recent years that, apart from the key role that thrombin plays in the blood coagulation cascade, thrombin also elicits cellular actions via the activation of proteinase-activated receptors, which are present in many cell types. These effects of thrombin are seen in a variety of physiological as well as pathological phenomena, including vascular development and physiology, tumor progression and metastasis, neuronal functions, inflammation, angiogenesis. Thrombin: Physiology and Disease, edited by Michael E. Maragoudakis and Nikos E. Tsopanoglou, emphasizes the new developments in this important field of research and provides the basis for translating these findings into therapeutic targets.".
Added Author
Maragoudakis, Michael E. editor.
Tsopanoglou, Nikos E. editor.
SpringerLink (Online service)
Subject
MEDICINE.
CANCER RESEARCH.
HUMAN PHYSIOLOGY.
PHARMACOLOGY.
EPIDEMIOLOGY.
BIOCHEMISTRY.
Biomedicine.
Human Physiology.
Cancer Research.
Pharmacology/Toxicology.
Biochemistry, general.
Epidemiology.
Multimedia
  • Libraries with this item
Total Ratings: 0
No records found to display.
 
 
 
03315nam a22005415i 4500
001
 
 
vtls001566928
003
 
 
VRT
005
 
 
20170831171300.0
007
 
 
cr nn 008mamaa
008
 
 
170831s2009    xxu|    s    |||| 0|eng d
020
$a 9780387096377 $9 978-0-387-09637-7
024
7
$a 10.1007/978-0-387-09637-7 $2 doi
035
$a (DE-He213)978-0-387-09637-7
039
9
$a 201708311713 $b santha $y 201708311228 $z vjs2012
050
4
$a QP34-38
072
7
$a MFG $2 bicssc
072
7
$a MED075000 $2 bisacsh
082
0
4
$a 612 $2 23
245
1
0
$a Thrombin $h [electronic resource] : $b Physiology and Disease / $c edited by Michael E. Maragoudakis, Nikos E. Tsopanoglou.
264
1
$a New York, NY : $b Springer New York : $b Imprint: Springer, $c 2009.
300
$a XII, 266 p. $b online resource.
336
$a text $b txt $2 rdacontent
337
$a computer $b c $2 rdamedia
338
$a online resource $b cr $2 rdacarrier
347
$a text file $b PDF $2 rda
505
0
$a Thrombin: Structure, Functions, and Regulation -- Thrombin: To PAR or Not to PAR, and the Regulation of Inflammation -- Regulation of Thrombin Receptor Signaling -- Thrombin-Activated Protein C: Integrated to Regulate Vascular Physiology -- The Role of Thrombin in Vascular Development -- The Role of Thrombin in Angiogenesis -- Thrombin and Thrombin Peptides in Wound Healing and Tissue Repair -- The Role of Thrombin and Thrombin Receptors in the Brain -- The Role of Thrombin in Tumor Biology -- The Role of Thrombin and its Receptors in Epithelial Malignancies: Lessons from a Transgenic Mouse Model and Transcriptional Regulation -- Anti-thrombotic Therapy in Cancer Patients -- Thrombin Receptor Modulators: Medicinal Chemistry, Biological Evaluation, and Clinical Application -- Novel Anticoagulant Therapy: Principle and Practice.
520
$a It has become increasingly evident in recent years that, apart from the key role that thrombin plays in the blood coagulation cascade, thrombin also elicits cellular actions via the activation of proteinase-activated receptors, which are present in many cell types. These effects of thrombin are seen in a variety of physiological as well as pathological phenomena, including vascular development and physiology, tumor progression and metastasis, neuronal functions, inflammation, angiogenesis. Thrombin: Physiology and Disease, edited by Michael E. Maragoudakis and Nikos E. Tsopanoglou, emphasizes the new developments in this important field of research and provides the basis for translating these findings into therapeutic targets.".
650
0
$a MEDICINE.
650
0
$a CANCER RESEARCH.
650
0
$a HUMAN PHYSIOLOGY.
650
0
$a PHARMACOLOGY.
650
0
$a EPIDEMIOLOGY.
650
0
$a BIOCHEMISTRY.
650
1
4
$a Biomedicine.
650
2
4
$a Human Physiology.
650
2
4
$a Cancer Research.
650
2
4
$a Pharmacology/Toxicology.
650
2
4
$a Biochemistry, general.
650
2
4
$a Epidemiology.
700
1
$a Maragoudakis, Michael E. $e editor.
700
1
$a Tsopanoglou, Nikos E. $e editor.
710
2
$a SpringerLink (Online service)
773
0
$t Springer eBooks
776
0
8
$i Printed edition: $z 9780387096360
856
4
0
$u http://dx.doi.org/10.1007/978-0-387-09637-7
912
$a ZDB-2-SBL
950
$a Biomedical and Life Sciences (Springer-11642)
999
$a VIRTUA               
No Reviews to Display
Summary
It has become increasingly evident in recent years that, apart from the key role that thrombin plays in the blood coagulation cascade, thrombin also elicits cellular actions via the activation of proteinase-activated receptors, which are present in many cell types. These effects of thrombin are seen in a variety of physiological as well as pathological phenomena, including vascular development and physiology, tumor progression and metastasis, neuronal functions, inflammation, angiogenesis. Thrombin: Physiology and Disease, edited by Michael E. Maragoudakis and Nikos E. Tsopanoglou, emphasizes the new developments in this important field of research and provides the basis for translating these findings into therapeutic targets.".
Contents
Thrombin: Structure, Functions, and Regulation -- Thrombin: To PAR or Not to PAR, and the Regulation of Inflammation -- Regulation of Thrombin Receptor Signaling -- Thrombin-Activated Protein C: Integrated to Regulate Vascular Physiology -- The Role of Thrombin in Vascular Development -- The Role of Thrombin in Angiogenesis -- Thrombin and Thrombin Peptides in Wound Healing and Tissue Repair -- The Role of Thrombin and Thrombin Receptors in the Brain -- The Role of Thrombin in Tumor Biology -- The Role of Thrombin and its Receptors in Epithelial Malignancies: Lessons from a Transgenic Mouse Model and Transcriptional Regulation -- Anti-thrombotic Therapy in Cancer Patients -- Thrombin Receptor Modulators: Medicinal Chemistry, Biological Evaluation, and Clinical Application -- Novel Anticoagulant Therapy: Principle and Practice.
Subject
MEDICINE.
CANCER RESEARCH.
HUMAN PHYSIOLOGY.
PHARMACOLOGY.
EPIDEMIOLOGY.
BIOCHEMISTRY.
Biomedicine.
Human Physiology.
Cancer Research.
Pharmacology/Toxicology.
Biochemistry, general.
Epidemiology.
Multimedia