P38δ regulates p53 to control p21 < sup > Cip1 < /sup > expression in human epidermal keratinocytes
P38δ regulates p53 to control p21 < sup > Cip1 < /sup > expression in human epidermal keratinocytes
| dc.contributor.author | Saha, Kamalika | |
| dc.contributor.author | Adhikary, Gautam | |
| dc.contributor.author | Kanade, Santosh R. | |
| dc.contributor.author | Rorke, Ellen A. | |
| dc.contributor.author | Eckert, Richard L. | |
| dc.date.accessioned | 2022-03-27T03:55:05Z | |
| dc.date.available | 2022-03-27T03:55:05Z | |
| dc.date.issued | 2014-04-18 | |
| dc.description.abstract | Background: Keratinocytes cease proliferation during differentiation, and the mechanism that mediates these events is not well understood. Results: PKCδ increases p38δ activity, which increases p53 transcription and acts to increase p21Cip1 promoter activity. Conclusion: PKCδ drives a MAPK cascade to increase p53 to control keratinocyte proliferation. Significance: This study provides detailed information regarding the mechanisms that control cell proliferation. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc. | |
| dc.identifier.citation | Journal of Biological Chemistry. v.289(16) | |
| dc.identifier.issn | 00219258 | |
| dc.identifier.uri | 10.1074/jbc.M113.543165 | |
| dc.identifier.uri | https://www.sciencedirect.com/science/article/abs/pii/S0021925820483590 | |
| dc.identifier.uri | https://dspace.uohyd.ac.in/handle/1/5975 | |
| dc.title | P38δ regulates p53 to control p21 < sup > Cip1 < /sup > expression in human epidermal keratinocytes | |
| dc.type | Journal. Article | |
| dspace.entity.type |
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