Synthesis and Cytotoxic Studies of Quinazoline-Triazole Hybrid Aza Heterocycles
Synthesis and Cytotoxic Studies of Quinazoline-Triazole Hybrid Aza Heterocycles
| dc.contributor.author | Vodnala, Sumathi | |
| dc.contributor.author | Bhavani, Anagani Kanaka Durga | |
| dc.contributor.author | Pagilla, Shankaraiah | |
| dc.contributor.author | Allam, Muralidhar | |
| dc.contributor.author | Rayala, Nagamani | |
| dc.contributor.author | Mudiraj, Anwita | |
| dc.contributor.author | Babu, Phanithi Prakash | |
| dc.date.accessioned | 2022-03-27T05:16:20Z | |
| dc.date.available | 2022-03-27T05:16:20Z | |
| dc.date.issued | 2021-11-01 | |
| dc.description.abstract | Abstract: Herein, we report a series of 1,2,3-triazole combined with quinazoline hybrid heterocyclic compounds by 1,3-dipolar cycloaddition reaction catalyzed by Cu(I). This reaction has been carried out between quinazoline based alkyne and aryl/benzyl azides under optimized conditions. Modification of 4-hydroxyquinazoline by propargyl bromide in presence of potassium carbonate gives a corresponding alkyne. Structure of the synthesized compounds has been characterized by IR, 1H, and 13C NMR, ESI-Mass, and HRMS spectra. The products have been tested for anticancer activity against C6 glioma cell lines and characterized by moderate cytotoxic activity. | |
| dc.identifier.citation | Russian Journal of General Chemistry. v.91(11) | |
| dc.identifier.issn | 10703632 | |
| dc.identifier.uri | 10.1134/S1070363221110189 | |
| dc.identifier.uri | https://link.springer.com/10.1134/S1070363221110189 | |
| dc.identifier.uri | https://dspace.uohyd.ac.in/handle/1/7611 | |
| dc.subject | 1,2,3-triazoles | |
| dc.subject | 1,3-dipolar cycloaddition | |
| dc.subject | azides | |
| dc.subject | cytotoxicity | |
| dc.subject | quinazoline | |
| dc.title | Synthesis and Cytotoxic Studies of Quinazoline-Triazole Hybrid Aza Heterocycles | |
| dc.type | Journal. Article | |
| dspace.entity.type |
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