Synthesis of methyl [6-(2-amino-1,3-thiazol-4-yl)-3-oxo-1,4-benzoxazin-2-yl] acetates as possible cox-2 / 5-lox inhibitors

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Date
2008-01-01
Authors
Reddy, G. Jagath
Rao, K. Srinivasa
Jayaveera, K. N.
Sailaja, S.
Reddanna, P.
Reddy, D. Bharat
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Abstract
A series of methyl [6-(2-aminothiazol-4-yl)-3-oxo-1,4-benzoxazin-2-yl]acetates (3-5) have been synthesized and tested for COX-2 (Cyclooxygenase) / 5-LOX (Lipoxygenase) inhibitory activity. Some of the compounds exhibited notable 5-LOX inhibitory activity. © 2008, by Walter de Gruyter GmbH & Co. All rights reserved.
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Heterocyclic Communications. v.14(1-2)