TARGETING OF STAT3 TO MITOCHONDRIA AND THE ROLE OF MITOCHONDRIAL STAT3 IN REDOX HOMEOSTASIS AND CELL CYCLE

Abstract

Mitochondria are membrane-bound organelles present in all eukaryotic cells that play a fundamental role in cellular energy production, thereby referred to as the “powerhouse of the cell,” ranging in size from 0.1 to 1 μm and are round or oval. Mitochondria are enclosed by two membranes, outer mitochondrial membrane, and inner mitochondrial membrane. These two membranes are divergent in their composition and function; they further define the two aqueous sub-compartments, Inter membrane space, and Matrix.