Mechanistic insights of dengue virus proteases [NS2B3 & NS] in host mitochondrial dynamics and evaluation of their potential as diagnostic and drug targets

Abstract

Research is the best hope for preventing and treating the diseases. Indeed, many advances have been made in virus research through which we have acquired important fundamental insights into virus biology. Despite these, much remains to be done, not only to prevent and cure the existing diseases, but also to fight against the newly emerging viruses. Though host develops immune defenses to restrict the pathogens, pathogens have acquired the ability to overcome these countermeasures. Hence, understanding these host-virus mechanisms is necessary to develop antiviral therapies and prevention strategies. The main motives of virus research are always to understand the biology of viruses and their hosts, and to discover novel antivirals and diagnostics for the improvement of public health. In the present study, we tried to enhance our understanding towards the role of dengue virus encoded protease in virus biology and its use in developing diagnostic assays and novel antivirals